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Cover Picture: Expansion and activation of CD4+CD25+ regulatory T cells in Heligmosomoides polygyrus infection – Eur. J. Immunol. 7/2007

✍ Scribed by Constance A. M. Finney; Matthew D. Taylor; Mark S. Wilson; Rick M. Maizels

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
616 KB
Volume
37
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

The cover shows a photograph of an individual adult Heligmosomoides polygyrus, a gastrointestinal nematode parasite and was provided by Finney et al. (pp. 1874–1886). In this study authors analyse in detail the development and phenotype (CTLA‐4, GITR, CD103) of cells responsible for the suppression of the early Th2 responses during murine H. polygyrus infection. Both CD25^+^Foxp3^+^ and CD25^+^Foxp3^‐^ subsets are increased during infection but, interestingly, only the latter display significant increases in TGF‐β levels.

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Expansion and activation of CD4+CD25+ re
Expansion and activation of CD4+CD25+ regulatory T cells in Heligmosomoides polygyrus infection
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