COVARIATE-ADJUSTED RESPONSE-ADAPTIVE DESIGNS FOR BINARY RESPONSE
β Scribed by Rosenberger, William F.; Vidyashankar, A. N.; Agarwal, Deepak K.
- Book ID
- 118231881
- Publisher
- Taylor and Francis Group
- Year
- 2001
- Tongue
- English
- Weight
- 110 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1054-3406
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π SIMILAR VOLUMES
## Abstract Most of the available responseβadaptive designs in phase III clinical trial set up are not from any optimal consideration. An optimal design for binary responses is given by Rosenberger et al. (2001) and an optimal design for continuous responses is provided by Biswas and Mandal (2004).
## Suiniitctry We propose R test statistic for discrimination between alternative bivariate binary response models and the optimal design procedtm which is an extension of 'T-optimality. Under certain conditions w e prove that the maximum value of the power ean be.obtained.when the degrees of free