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Covalently Cross-Linked Watson–Crick Base Pair Models

✍ Scribed by Xiaoxin Qiao; Yoshito Kishi

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
160 KB
Volume
38
Category
Article
ISSN
0044-8249

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✦ Synopsis

Structural characteristics of Watson-Crick hydrogen-bonded base pairs are displayed by methylene-bridged base pairs of type A. The shown superposition of the X-ray structure obtained for the base pair A (Rib =Et; Rib =Me) over that of a C-G base pair illustrates that A occupies an area similar to that occupied by a traditional Watson-Crick hydrogen-bonded base pair. Temperature-dependent H NMR studies indicate that the energy barrier for rotation along its CH bridge is about 10 kcal mol , and that it exists predominantly in one conformer at -70°C.

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