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Covalent linkage of the synthetic adjuvant MDP to the synthetic polypeptide (T,G)-A—L changes the specificity of the immune response at the T and B cell level

✍ Scribed by Orly Abehsira-Amar; Michèle Uzan; Françoise Audibert; Michel Jolivet; Louis Chedid; Jacques Theze


Book ID
119089659
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
826 KB
Volume
24
Category
Article
ISSN
0161-5890

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✍ M. Sela; Sara Fuchs; Ruth Maron; Bela Gertner 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 English ⚖ 432 KB

The immunogenicity of the synthetic multichain polypeptide (T,G)-A-L in rabbits was investigated under a variety of conditions. The polymer led t o antibody production with as little as four micrograms in complete Freund's adjuvant per immunization. The pattern of antibody formation as a function of