Coupling of β-acetamido radicals with α-chloro-acrylonitrile — a new access to disubstituted proline derivatives

Structure determination of a trans-octah

Structure determination of a trans-octahydroindole derivative obtained by consecutive coupling of a β-acetamido radical with α-chloroacrylonitrile and cyclisation

✍ R. Henning; H. Urbach; E.F. Paulus 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 204 KB

The determination of the structure of 1-acetyl-octahydroindole-2carbonitrile by NMR spectroscopy, X-ray diffraction and computerized conformational analysis is described. We have prepared 1-acetyl-octahydroindole-2-carbonitrile (2) by acetamidomercuration of cyclohexene, followed by reductive coupl