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Coupling caspase cleavage and ubiquitin–proteasome-dependent degradation of SSRP1 during apoptosis

✍ Scribed by Landais, I; Lee, H; Lu, H


Book ID
110017179
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
450 KB
Volume
13
Category
Article
ISSN
1350-9047

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## Abstract Multidrug resistance (MDR) mediated by the drug efflux protein, 170‐kDa P‐glycoprotein (P‐gp), is one mechanism that tumor cells use to escape cell death induced by chemotherapeutic drugs. Moreover, evidence suggests that cell lines expressing high levels of 170‐kDa P‐gp are less sensit