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Cleavage and degradation of Claspin during apoptosis by caspases and the proteasome

✍ Scribed by Semple, J I; Smits, V A J; Fernaud, J-R; Mamely, I; Freire, R

Book ID
110017425
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
504 KB
Volume
14
Category
Article
ISSN
1350-9047

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The oncogene Akt/PKB/RAC-PK is a serine/threonine kinase that mediates survival signals and has protective effects against apoptosis induced by a variety of stimuli. The kinase activity of Akt has been demonstrated to be critical in transmitting survival signals. We found that Akt protein was down-r