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Coumarin-induced skin necrosis associated with acquired protein s deficiency and antiphospholipid antibody syndrome

✍ Scribed by Marie-José Wattiaux; Robert Hervé; Annie Robert; Jean Cabane; Bruno Housset; Jean-Claude Imbert


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
418 KB
Volume
37
Category
Article
ISSN
0004-3591

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Skin necrosis is a rare but debilitating complication of treatment with vitamin K antagonist anticoagulants such as warfarin. A clinically similar syndrome has been reported less frequently with heparin therapy. We recently managed a thirty-year-old female patient who developed skin necrosis on her