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Costimulation of T cells by OX40, 4-1BB, and CD27

✍ Scribed by Michael Croft


Book ID
117757711
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
197 KB
Volume
14
Category
Article
ISSN
1359-6101

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## Abstract The T cell surface protein CD28 provides a critical costimulatory signal for T cell activation. With age, humans accumulate increasing numbers of CD28^–^ T cells, and this loss of CD28 expression is exacerbated certain disease states, such as HIV infection, autoimmune conditions or canc