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Cortical myoclonus in levodopa-responsive parkinsonism

✍ Scribed by John N. Caviness; Charles H. Adler; Stephanie Newman; Richard J. Caselli; Manfred D. Muenter

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
469 KB
Volume
13
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

We observed myoclonic movements of the fingers and wrists in two patients with a levodopa‐responsive parkinsonian syndrome most consistent with Parkinson's disease. These patients were studied with electrophysiological techniques. Brief (< 50 ms) myoclonic electromyographic discharges showed a time‐locked relationship to a focal premovement electroencephalographic potential. Somatosensoryevoked potentials were not enlarged and long‐latency reflexes were not grossly exaggerated. This pattern of electrophysiological findings can be distinguished from those previously found in other parkinsonian syndromes. These results provide evidence for a cortical origin of the myoclonus seen in these patients.

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