Cisplatin is a widely used chemotherapeutic agent in head and neck squamous cell carcinoma (HNSCC). Resistance to cisplatin is a common feature of HNSCC. To identify genes that may regulate cisplatin sensitivity, we carried out a cDNA microarray analysis of gene expression in cisplatin-sensitive and
Corrigendum to “Relationship of glutathine and glutathione-S-transferase to cisplatin sensitivity in human head and neck squamous carcinoma cell lines”
✍ Scribed by Yellin, Seth A.; Davidson, Bruce J.; Pinto, John T.; Sacks, Peter G.; Qiao, Changhong; Schantz, Stimson P.
- Book ID
- 122055256
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 61 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0304-3835
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Glutathione S-transferases (GSTs) are metabolic phase II enzymes that promote reactive metabolite elimination by conjugating them to glutathione (GSH). Because of their important role in xenobiotic metabolism and detoxification, they have been implicated in carcinogenesis processes, especially epith
## Abstract ## Background Resistance to chemotherapy is a major limitation in the treatment of head and neck squamous cell carcinomas (HNSCCs), accounting for high mortality rates in patients. Here, we investigated the role of replication protein A (RPA) in cisplatin and etoposide resistance. ##