𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Correlation of immunomodulatory and therapeutic activities of interferon and interferon inducers in metastatic disease

✍ Scribed by Paul L. Black; Hamblin Phillips; Henry R. Tribble; Robin Pennington; Mark Schneider; James E. Talmadge

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
942 KB
Volume
36
Category
Article
ISSN
0730-2312

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✦ Synopsis

The mechanism of therapeutic activity of recombinant murine interferon-gamma (rMu IFN-y) and the IFN inducer polyinosinic-polycytidylic acid solubilized with poly-L-lysine in carboxy methyl cellulose (pICLC) in treating metastatic disease was investigated by comparing effector cell augmentation with therapeutic activity in mice bearing experimental lung metastases (B16-BL6 melanoma). Effector cell functions in spleen, peripheral blood, and lung (the organ with tumor) were tested after 1 and 3 weeks of rMu IFN-.I or pICLC administration (intravenous, three times a week). In these studies, natural killer (NK), lymphokine-activated killer (LAK), cytolytic T lymphocytes (CTL) (against specific and nonspecific targets), and macrophage tumoricidal and tumoristatic activities were measured. rM IFN-y and pICLC had therapeutic activity and immunomodulatory activity in most assays of immune function examined. Specific CTL activity of pulmonary parenchymal mononuclear cells (PPMC), but not in splenocytes or peripheral blood lymphocytes (PBL), during week 3 and not during week 1, correlated with the therapeutic activity of rMu IFN-y and of pICLC. Macrophage tumoricidal activity in PPMC, but not in alveolar macrophages, also correlated with the therapeutic activity of rMu IFN-y, but the opposite was true for the therapeutic activity of pICLC. NK

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