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Correlation of dna flow cytometric results and other prognostic factors in primary breast cancer

✍ Scribed by G. E. Feichter; A. Mueller; M. Kaufmann; D. Haag; I. A. Born; U. Abel; K. Klinga; F. Kubli; K. Goerttler

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
598 KB
Volume
41
Category
Article
ISSN
0020-7136

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✦ Synopsis

The percentage of cells in S-phase and DNA-ploidy have been measured in 300 primary mammary carcinomas by means of DNA-flow cytometry (FCM). The data were compared with the age and menopausal status of the patients as well as with the size, regional lymph-node involvement, histologic type, grade and concentration of estrogen (ER) and progesterone (PR) receptors of the tumors. A DNA-diploid distribution of the Go,l-peak was found in 37.69b of the cases. The mean percentage of S-phase fractions was 4.83. DNAaneuploid tumors had significantly higher amounts of S-phase fractions (6.12%) than DNA-diploid tumors (2.66%). There was also a significant correlation between the DNA measurement data (DNA-ploidy and S-phase fractions) and histologic grade, as well as the content of ER and PR, but not between DNAploidy. S-phase fractions, tumor size (T) and evidence of axillary lymph-node metastases. DNA-FCM gives a biological characterization of the tumor in addition to the histopathologic examination. The method can be used as a routine procedure because of the reliability and reproducibility of the results as well as the short time needed for the measurements.

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