Correlation between pharmacokinetics and pharmacologic effects of a new imidazole thromboxane synthetase inhibitor
โ Scribed by Toshio Iwata; Hiroshi Mikashima; Rikuo Takamatsu
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 676 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Synthesis of [^3^H]FCE 22178, namely 5,6โdihydroโ7โ(1Hโ[Gโ^3^H]imidazolโ1โyl)โnaphthaleneโ2โcarboxylic acid 5 was performed in three steps from 5,6,7,8โtetrahydroโ8โhydroxyโ7โ(1Hโimidazolโ1โyl)โnaphtaleneโ2โcarboxylic acid 2 by bromination, catalytic tritiation and final dehydration, in
The pharmacokinetics and pharmacologic effects of a potent, selective inhibitor of thromboxane synthetase, CV-4151 [(E)-7-phenyl-7-(3-pyridyl)-6-heptenoic acid] on prostanoid formation and platelet aggregation were studied in 42 healthy male volunteers. The drug was well tolerated. After oral admini