✦ LIBER ✦
Synthesis of tritium labelled 5,6-dihydro-7-(1H-imidazol-1-YL)-naphthalene-2-carboxylic acid (FCE 22178), a new thromboxane synthetase inhibitor
✍ Scribed by Erminia Fontana; Gian Piero Vicario
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 257 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
Synthesis of [^3^H]FCE 22178, namely 5,6‐dihydro‐7‐(1H‐[G‐^3^H]imidazol‐1‐yl)‐naphthalene‐2‐carboxylic acid 5 was performed in three steps from 5,6,7,8‐tetrahydro‐8‐hydroxy‐7‐(1H‐imidazol‐1‐yl)‐naphtalene‐2‐carboxylic acid 2 by bromination, catalytic tritiation and final dehydration, in an overall radiochemical yield of 48%. The product was 97% radiochemically pure and had a specific radioactivity of 9.15 GBq/mmol.