✦ LIBER ✦

Correlation between lymphatic vessel density and regional metastasis in squamous cell carcinoma of the tongue

✍ Scribed by Man Ki Chung; Jin-Young Min; Yoon Kyoung So; Young-Hyeh Ko; Han-Sin Jeong; Young-Ik Son; Chung-Hwan Baek

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 432 KB
Volume: 32
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21202

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background.

The aim of this study was to investigate the correlation between lymphatic vessel density in squamous cell carcinoma of the tongue and regional metastasis.

Methods.

Intratumoral and peritumoral lymphatic densities (ILDs and PLDs, respectively) were determined by immunohistochemical staining of lymphatic endothelial cells with podoplanin in 62 patients surgically treated for tongue cancer. Clinicopathological variables were quantified, and their correlations with regional metastasis were assessed.

Results.

The rate of regional metastasis was significantly higher in patients with high ILD than that in those with low ILD (21/33, 63.6% vs 8/29, 27.5%; p = .006). Perineural invasion and lymphovascular invasion were also significantly correlated with regional metastasis. By multivariate analyses, ILD was the only variable identified to be significantly correlated with regional metastasis (p = .009). On the other hand, PLD showed no correlation with regional metastasis.

Conclusions.

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