Correlation between in vitro and in vivo concentration–effect relationships of naproxen in rats and healthy volunteers
✍ Scribed by Dymphy R H Huntjens; David J M Spalding; Meindert Danhof; Oscar E Della Pasqua
- Book ID
- 110009127
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 199 KB
- Volume
- 148
- Category
- Article
- ISSN
- 0007-1188
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The effect of surfactants on percutaneous absorption of naproxen was studied using rat in vivo models. The in vivo normalized relative absorption rates were in good agreement with the in vitro relative flux. An antipyretic model in the rat could not show relatively small increases in percutaneous ab
The relationship between dose and bioavailability of propranolol was determined in 12 healthy male subjects. The doses employed were 10, 40, 80 or 160mg of propanolol HCI given three times daily for 4 days. Daily minimum plasma levels showed that there was no accumulation of the drug. In all subject