✦ LIBER ✦

Correlation and prediction of blood-brain distribution

✍ Scribed by HarpreetS. Chadha; MichaelH. Abraham; RobertC. Mitchell

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 303 KB
Volume: 11
Category: Article
ISSN: 0263-7855
DOI: 10.1016/0263-7855(93)80059-z

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Ionization-specific prediction of blood–

Ionization-specific prediction of blood–brain permeability

✍ Kiril Lanevskij; Pranas Japertas; Remigijus Didziapetris; Alanas Petrauskas 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 212 KB

This study presents a mechanistic QSAR analysis of passive blood-brain barrier permeability of drugs and drug-like compounds in rats and mice. The experimental data represented in vivo log PS (permeability-surface area product) from in situ perfusion, brain uptake index, and intravenous administrati

Blood-brain exchange routes and distribu

Blood-brain exchange routes and distribution of65Zn in rat brain

✍ P. A. Franklin; R. G. L. Pullen; G. H. Hall 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 577 KB

QSAR analysis of blood–brain distributio

QSAR analysis of blood–brain distribution: The influence of plasma and brain tissue binding

✍ Kiril Lanevskij; Justas Dapkunas; Liutauras Juska; Pranas Japertas; Remigijus Di 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 471 KB

The extent of brain delivery expressed as steady-state brain/blood distribution ratio (log BB) is the most frequently used parameter for characterizing central nervous system exposure of drugs and drug candidates. The aim of the current study was to propose a physicochemical QSAR model for log BB pr

TOPS-MODE approach for the prediction of

TOPS-MODE approach for the prediction of blood–brain barrier permeation

✍ Miguel Angel Cabrera; Marival Bermejo; Maykel Pérez; Ronal Ramos 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 233 KB

The blood-brain barrier permeation has been investigated by using a topological substructural molecular design approach (TOPS-MODE). A linear regression model was developed to predict the in vivo blood-brain partitioning coefficient on a data set of 119 compounds, treated as the logarithm of the blo

Prediction of drug distribution in distr

Prediction of drug distribution in distribution dialysis and in vivo from binding to tissues and blood

✍ J. Clausen; M. H. Bickel 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 498 KB

Clinical correlations of brain lesion di

Clinical correlations of brain lesion distribution in multiple sclerosis

✍ M.M. Vellinga; J.J.G. Geurts; E. Rostrup; B.M.J. Uitdehaag; C.H. Polman; F. Bark 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 220 KB

## Abstract ## Purpose To explore relations between spatial distribution of multiple sclerosis (MS) lesions, and disability. In MS, the presence of asymptomatic brain lesions challenges the prediction of disability based on conventional brain MRI. Hypothesizing that symptomatology may partly be de