Correction of thiazide hyperuricemia by potassium chloride and ammonium chloride

✍ Scribed by Andrew J. Zweifler; George R. Thompson

• Publisher: John Wiley and Sons
• Year: 1965
• Tongue: English
• Weight: 815 KB
• Volume: 8
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780080612

✦ Synopsis

Large doses of KCI lowered serum uric acid while producing mild, apparently unrelated, uricosuria in four chlorothiazide-treated subjects. In two control subjects KCI also caused mild uricosuria, but had a negligible effect on serum uric acid concentration. Ammonium chloride decreased serum urate in all six subjects, while urinary uric acid excretion remained essentially unchanged. It is suggested that these changes in serum uric acid are secondary to redistribution of urate among body compartments.