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Correction of the published sequence for the human proteolipid protein gene

✍ Scribed by Paul J. Wilkins; Cynthia R. D'Souza; Peter J. Bridge

Book ID
104661157
Publisher
Springer
Year
1991
Tongue
English
Weight
203 KB
Volume
86
Category
Article
ISSN
0340-6717

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✦ Synopsis

In the human proteolipid protein gene, the base sequence of the intronic region 5' to exon 6 was found to be 5'-ctctttcattttcctgcag-3' and not 5'-ctcttttcattttcctgcag-3' as previously reported. P M D using the method of, and same primers as, Gencic et al. (1989). These primers are complementary to sequences more deeply embedded in the introns than the sequence published by Diehl et al. (1986) and therefore allow an independent check of the original data.

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A full-length clone for the human proteolipid protein (PLP) was isolated from a cDNA library constructed from poly(A)+ RNA isolated from fetal spinal cords obtained at 15-24 weeks of conceptional age. The sequence of the human PLP cDNA was determined, and the deduced amino acid sequence was found to