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Correction of retinal abnormalities found in albinism by introduction of a functional tyrosinase gene in transgenic mice and rabbits

✍ Scribed by Glen Jeffery; Gottfried Brem; Lluis Montoliu

Book ID: 114134462
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 729 KB
Volume: 99
Category: Article
ISSN: 0165-3806
DOI: 10.1016/s0165-3806(96)00211-8

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## Abstract Summary: Deletion of the tyrosinase locus control region (LCR) in transgenic mice results in variegated expression in the skin. Here we investigate the pigmentation pattern of other tissues that express tyrosinase: iris, choroid, and retina in the same animals. A mosaic distribution of