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Copper(I)-Catalyzed Regio- and Chemoselective Single and Double Addition of Nucleophilic Silicon to Propargylic Chlorides and Phosphates

โœ Scribed by Hazra, Chinmoy K.; Oestreich, Martin


Book ID
118002167
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
273 KB
Volume
14
Category
Article
ISSN
1523-7060

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## Abstract Activation of the Si๏ฃฟB interโ€element bond with copper(I) alkoxides produces copperโ€based silicon nucleophiles that react readily with aldehydes to yield ฮฑโ€silyl alcohols (that is, ฮฑโ€hydroxysilanes) after hydrolysis. Two independent protocols were developed, one employing a wellโ€defined