Copper protection in the palladium catalyzed regioselective allylation of a model polyketide: Methyl 3,5-dioxohexanoate

✍ Scribed by Jorge Marquet; Marcial Moreno-Mañas; María Prat

• Book ID: 104229566
• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 228 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)99414-0

✦ Synopsis

Bellaterra. 08193~Barcelona. Spain.

Sumnary.-Regioselective allylation of the model polyketide system methyl 3,5_dioxohexanoate at the C-2 position can be accomplished even with secondary and tertiary radicals by palladium catalyzed allylation of its copper complex, la. Initial results indicate that the cobalt(I1) complex, lb, can be also useful. Cyclizations of the resulting diketoesters,