Copper metabolism in the rat: effects of copper loading and copper depletion

✍ Scribed by V. Albergoni; N. Favero; G.P. Rocco

• Publisher: Elsevier Science
• Year: 1978
• Weight: 927 KB
• Volume: 9
• Category: Article
• ISSN: 0006-3061
• DOI: 10.1016/s0006-3061(00)80151-9

✦ Synopsis

Variations of -the copper distributions subsequentto copper imput changes have been studied in normalmale Wistar rats. A fasting period (48 or 96 hr) produces sigaiBcmt variations only &i the kidneys. D-P-e admh--s istered during the fasting period induces a sigoiiicant decrease of the copper cant+ also in :the. liver-W@F_ i&x+ s++*eou+ CuC12~~~-2 .*g body w$glhj ktoreihp first in the liver and second in me khneys (24 br after a 2-m&g body-weight injection. 80% of the copper is found in t&liver and . 6% in the ki&e& b-Penicikmine &mini&ered~&&taueo&. to animals _ treated with'kuCI~ brix& &e ex&edii&cqppe; of t.@ Iivei t0 31onniI i&es within 6~ hr. A prominent roIe of tEk liver and ihe k&e~ in th& upper -' 3T%?-is-:I:,_ _ .