The Long-Evans Cinnamon rat is a mutant strain that contracts hereditary hepatitis and, eventually, spontaneous hepatocellular carcinoma. Because we found a corresponding gross copper accumulation in the liver of the rats, we examined whether the development of hepatitis in our rat system could be p
โฆ LIBER โฆ
Age-related copper, zinc, and iron metabolism in Long-Evans cinnamon rats and copper-eliminating effects of D-penicillamine and trienthine-2HCl
โ Scribed by Norikazu Shimizu; Yoshimi Fujii; Yoko Saito; Yukitoshi Yamaguchi; Tsugutoshi Aoki
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 153 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0896-548X
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To understand the unique pathophysiological process of LEC rats (Long-Evans rats with a cinnamon-like coat color), which develop hereditary and spontaneous hepatic injury โผ4 months after birth, the levels of four biometals, such as Cu, Fe, Zn, and Mn together with metallothionein (MT) and nitric oxi