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Copper-Catalyzed Synthesis of α-Amino Imides from Tertiary Amines: Ugi-Type Three-Component Assemblies Involving Direct Functionalization of sp 3 C−Hs Adjacent to Nitrogen Atoms

✍ Scribed by Ye, Xin; Xie, Chunsong; Pan, Yuanyuan; Han, Laihong; Xie, Tian

Book ID: 120595289
Publisher: American Chemical Society
Year: 2010
Tongue: English
Weight: 297 KB
Volume: 12
Category: Article
ISSN: 1523-7060
DOI: 10.1021/ol101576q

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✦ Synopsis

α-Amino imides can be accessed straightforwardly from tertiary amines through copper-catalyzed three-component reactions involving the direct functionalization of sp(3) C-Hs adjacent to nitrogen atoms. This reaction has demonstrated a tolerance to a wide range of functionalizations and can be performed under very mild conditions. A plausible mechanism has been proposed in which an Ugi-type cascade assembly has been included.

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