Copper-Catalyzed Synthesis of a Highly Hydroxy-Functionalized Benzo[ e ]indolizidine by Intramolecular N -Arylation
✍ Scribed by Cordero, Franca M.; Khairnar, Bhushan B.; Bonanno, Paola; Martinelli, Andrea; Brandi, Alberto
- Book ID
- 120541414
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 584 KB
- Volume
- 2013
- Category
- Article
- ISSN
- 1434-193X
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📜 SIMILAR VOLUMES
## Abstract DBU‐promoted alkylation of cyclic α‐nitroketones (I) with o‐bromobenzyl halides, e.g. (II), (V) or (VIII), followed by Pd‐catalyzed intramolecular C‐arylation provides an efficient access towards benzo‐fused bicyclo[n.3.1]alkane derivatives (III), (VI) and (IX), respectively.
Facile intramolecular N-arylation catalyzed by CuI/L-proline has been developed to prepare 6,12b-diazadibenzo[a,h]azulen-7-ones and benzo[f]pyrrolo[1,2-a][1,4]diazepin-4-ones in good to excellent yields.