Synthesis of benzo- and naphtho-fused bicyclo[n.3.1]alkane frameworks with a bridgehead nitrogen function by palladium-catalyzed intramolecular α′-arylation of α-nitroketones

ChemInform Abstract: Synthesis of Benzo-

ChemInform Abstract: Synthesis of Benzo- and Naphtho-Fused Bicyclo[n.3.1]alkane Frameworks with a Bridgehead Nitrogen Function by Palladium-Catalyzed Intramolecular α′-Arylation of α-Nitroketones.

✍ Giorgio Giorgi; Swarupananda Maiti; Pilar Lopez-Alvarado; J. Carlos Menendez 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 38 KB 👁 1 views

## Abstract DBU‐promoted alkylation of cyclic α‐nitroketones (I) with o‐bromobenzyl halides, e.g. (II), (V) or (VIII), followed by Pd‐catalyzed intramolecular C‐arylation provides an efficient access towards benzo‐fused bicyclo[n.3.1]alkane derivatives (III), (VI) and (IX), respectively.