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Copper-Catalyzed Oxidative Trifluoromethylation of Terminal Alkenes Using Nucleophilic CF3SiMe3: Efficient C(sp3)–CF3 Bond Formation

✍ Scribed by Chu, Lingling; Qing, Feng-Ling


Book ID
115470623
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
300 KB
Volume
14
Category
Article
ISSN
1523-7060

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Copper-catalyzed oxidative trifluorometh
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Copper-catalyzed trifluoromethylation via oxidative sp 3 C-H activation at the a-position of nitrogen in tetrahydroisoquinoline derivatives using DDQ and Ruppert-Prakash reagent has been successfully achieved. The reaction of various amines gave the corresponding trifluoromethylated products in 15-9