## Abstract An efficient catalytic enantioselective hetero‐Diels–Alder reaction of Danishefsky's diene with aldehydes using the magnesium binaphthoxide system has been developed, affording a variety of 2‐substituted 2,3‐dihydro‐4__H__‐pyran‐4‐ones in high yields and with excellent __ee__ values. Th
Copper-Catalyzed Enantioselective Hetero-Diels–Alder Reaction of Danishefsky’s Diene with β,γ-Unsaturated α-Ketoesters
✍ Scribed by Hu, Yanbin; Xu, Kun; Zhang, Sheng; Guo, Fengfeng; Zha, Zhenggen; Wang, Zhiyong
- Book ID
- 127132170
- Publisher
- American Chemical Society
- Year
- 2014
- Tongue
- English
- Weight
- 485 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1523-7060
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## Abstract Highly enantioselective Diels–Alder (DA) and inverse‐electron‐demand hetero‐Diels–Alder (HDA) reactions of β,γ‐unsaturated α‐ketoesters with cyclopentadiene catalyzed by chiral __N__,__N′__‐dioxide–Cu(OTf)~2~ (Tf=triflate) complexes have been developed. Quantitative conversion of β,γ‐un
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## Abstract A new type of dendritic 2‐amino‐2′‐hydroxy‐1,1′‐binaphthyl (NOBIN)‐derived Schiff‐base ligands have been synthesized and applied to the titanium‐catalyzed hetero‐Diels–Alder reaction of Danishefsky's diene with aldehydes. These reactions afforded the corresponding 2‐substituted 2,3‐dihy