Copper-catalyzed enantioselective conjugate addition of diethylzinc to α,β-unsaturated carbonyl compounds using diphosphonites as chiral ligands

✍ Scribed by Manfred T. Reetz; Andreas Gosberg; Dominique Moulin

• Book ID: 104232395
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 57 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)02355-3

✦ Synopsis

BINOL-based diphosphonites in which ferrocene functions as the achiral backbone are excellent chiral ligands in the Cu(OTf) 2 -catalyzed conjugate addition of Et 2 Zn to enones, enantioselectivities of up to 99% being observed.