Chiral Copper(II)-Catalyzed Enantioselective Boron Conjugate Additions to α,β-Unsaturated Carbonyl Compounds in Water
✍ Scribed by Kobayashi, Shū; Xu, Pengyu; Endo, Toshimitsu; Ueno, Masaharu; Kitanosono, Taku
- Book ID
- 118752349
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 353 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0044-8249
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📜 SIMILAR VOLUMES
BINOL-based diphosphonites in which ferrocene functions as the achiral backbone are excellent chiral ligands in the Cu(OTf) 2 -catalyzed conjugate addition of Et 2 Zn to enones, enantioselectivities of up to 99% being observed.
The enantioselective copper-catalyzed 1,4-addition of Grignard reagents to a$-unsaturated carbonyl compounds was studied with the following Cu' compounds as catalyst precursor and 1,2 : 5,6-di-0 -isopropylidene-3thio-a -o-glucofuranose (Hsiig) as chiral ligand: CuI, iodo[bis(dibutylsulfide)]copper(I