Direct C2-trifluoromethylation of indole
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Ryo Shimizu; Hiromichi Egami; Tatsuya Nagi; Jungha Chae; Yoshitaka Hamashima; Mi
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Article
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2010
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Elsevier Science
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French
β 306 KB
Direct C2-selective trifluoromethylation of indole derivatives was achieved with Togni's hypervalent iodine reagent and CuOAc as a catalyst in MeOH under mild conditions, affording the desired C2-trifluoromethylated indoles in good yield (up to 90%).