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Copper-Catalyzed Direct C-2 Difluoromethylation of Furans and Benzofurans: Access to C-2 CF 2 H Derivatives

✍ Scribed by Belhomme, Marie-Charlotte; Poisson, Thomas; Pannecoucke, Xavier


Book ID
126880313
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
880 KB
Volume
79
Category
Article
ISSN
0022-3263

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Direct C2-trifluoromethylation of indole
✍ Ryo Shimizu; Hiromichi Egami; Tatsuya Nagi; Jungha Chae; Yoshitaka Hamashima; Mi πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 French βš– 306 KB

Direct C2-selective trifluoromethylation of indole derivatives was achieved with Togni's hypervalent iodine reagent and CuOAc as a catalyst in MeOH under mild conditions, affording the desired C2-trifluoromethylated indoles in good yield (up to 90%).