Copper-Catalyzed Coupling Reaction of Terminal Alkynes with Aryl- and Alkenyliodonium Salts
β Scribed by Kang, Suk-Ku; Yoon, Seok-Keun; Kim, Young-Mook
- Book ID
- 120393997
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 91 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1523-7060
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π SIMILAR VOLUMES
Coupling reaction of aryl and vinyl halides with terminal alkynes using a catalyst system of copper(I) iodide -triphenylphosphine proceeds efficiently in the presence of potassium carbonate to give the corresponding unsymmetrical acetylenes in good yield.
A palladium-catalyzed cross-coupling reaction of aryl trimethoxysilanes with terminal alkynes was described. Thus, di-substituted alkynes were prepared in moderate to good yields. The electron-deficient terminal alkynes also worked well in the procedure.
## Abstract A copperβcatalyzed crossβcoupling reaction of alkynes with aryl iodides is described. The system tolerates a broad range of functional groups and enables the use of sterically demanding substrates with only 1.0β2.5 molβ% of Cu~2~O and 1.0β2.5 molβ% of xantphos as the catalyst.