5,6-Dihydroxyindole (5,6DHI) and 5,6-dihydroxyindole-2-carboxylic acid (5,6DHI2C) are ultimate precursors of the black melanin, eumelanin. These indolic metabolites and their O-methyl derivatives are excreted in urine of melanoma patients at high levels and of healthy persons at low levels. We descr
Copolymerisation of 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid in melanogenesis: Isolation of a cross-coupling product
โ Scribed by Alessandra Napolitano; Orlando Crescenzi; Giuseppe Prota
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 250 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Mammalian melanins exist in two chemically disnylalanine (dopa), 3 which is produced from tyrosine tinct forms: the brown to black eumelanins and the by the action of tyrosinase. Dopaquinone undergoes yellow to reddish pheomelanins. Eumelanins are dea series of redox reactions leading to eumelanin f
A method for the determination of the urinary melanocyte metabolite 5,6-dihydroxyindole-2-carboxylic acid is described. The catecholic indole is adsorbed onto alumina, chromatographed on a reverse-phase octadecyl silica column, and detected by fluorometry. The sensitivity of the method permits detec
Matrix-assisted laser desorptionhonization mass spectrometry was applied to the structural investigation of synthetic melanins prepared by enzymatic or chemical oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA), a major biosynthetic precursor. Following optimization of the experimental cond
Despite extensive efforts over more than half a century, the direct structural investigation of natural melanins has, so far, been largely unsuccessful, because of the adverse physical and chemical properties of these pigments. In the present study, we applied matrix-assisted laser desorption/ioniza