Coordination of adenosine and ATP to Pd(II)-Glycyl-L-aspartic acid complex

✍ Scribed by H. Kozlowski

• Publisher: Elsevier Science
• Year: 1977
• Tongue: English
• Weight: 426 KB
• Volume: 24
• Category: Article
• ISSN: 0020-1693
• DOI: 10.1016/s0020-1693(00)93877-5

✦ Synopsis

The Pd(II) dipeptide complex forms the monoand dimeric species with adenosine and ATP. At higher pH the Pd(II) favours the NI over N7 coordination in nucleoside and nucleotide molecule. At pH above IO adenosine is unbound and promotes a "'double" hydrolysis of the Pd-dipeptide complex. The ATP forms much more stable comple.xes than adenosine and even at pH above 10 in 2:l solution the Pd-Nl species is the dominant one (80% of ATP). The Pd-GLYASPA complex acts as a monodentate species and the coordination of two adjacent nucleotides has not been observed. Also the chelation by nucleoside or nucleotide is a minor form of interaction and it has not been found.

was also commercially available (Merck) and used without further purification. PMR spectra were recorded on a JEOL 100 MHz JNM-PS-100 spectrometer using t-butanol as an internal standard. All chemical shifts were converted to DSS reference. The spectra were recorded at 25 + 1 "C. The pH was measured on a Mera-Elmat N-5 112 pH-meter. Analysis of the NMR spectra was made on a JEC-6 computer.

The concentration of Pd(II) ions in all measurements was 0.1 M.