✦ LIBER ✦

Coordinated regulation of type I and type III collagen production and mRNA levels of pro α1(I) and pro α2(I) collagen in cultured morphea fibroblasts

✍ Scribed by T. Vuorio; J. K. Mäkelä; V.-M. Kähäri; E. Vuorio

Publisher: Springer-Verlag
Year: 1987
Tongue: English
Weight: 832 KB
Volume: 279
Category: Article
ISSN: 0340-3696
DOI: 10.1007/bf00413250

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Procollagen gene expression by scleroder

Procollagen gene expression by scleroderma fibroblasts in culture. inhibition of collagen production and reduction of proα(i) and proα1(III) collagen messenger RNA steady-state levels by retinoids

✍ Akihide Ohta; Jouni Uitto 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 843 KB

Increment of pro α1 (I) and pro α1 (IV)

Increment of pro α1 (I) and pro α1 (IV) collagen mRNA steady-state levels by EGF stimulated hepatocytes in primary culture

✍ Motomura, M. ;Ozaki, I. ;Fujio, N. ;Setoguchi, Y. ;Yamamoto, K. ;Kariya, T. ;Sak 📂 Article 📅 1990 🏛 Springer-Verlag 🌐 English ⚖ 129 KB

Role of the pro-α2(I) COOH-terminal regi

Role of the pro-α2(I) COOH-terminal region in assembly of type I collagen: Disruption of two intramolecular disulfide bonds in pro-α2(I) blocks assembly of type I collagen

✍ Sharon A. Doyle; Barbara D. Smith 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB 👁 1 views

Collagen biosynthesis is a complex process that begins with the association of three procollagen chains. A series of conserved intra-and interchain disulfide bonds in the carboxyl-terminal region of the procollagen chains, or C-propeptide, has been hypothesized to play an important role in the nucle

Role of the pro-α2(I) COOH-terminal regi

Role of the pro-α2(I) COOH-terminal region in assembly of type I collagen: Truncation of the last 10 amino acid residues of pro-α2(I) chain prevents assembly of type I collagen heterotrimer

✍ Ai-lee Lim; Sharon A. Doyle; Gary Balian; Barbara D. Smith 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 325 KB 👁 1 views

Procollagen (Type I) contains a noncollagenous COOH-terminal propeptide (C-propeptide) hypothesized to be important in directing chain association and alignment during assembly. We previously expressed human pro-␣2(I) cDNA in rat liver epithelial cells, W8, that produce only pro-␣1(I) trimer collage

Activation of type I collagen genes in c

Activation of type I collagen genes in cultured scleroderma fibroblasts

✍ Tuula Vuorio; Jyrki K. Mäkelä; Eero Vuorio 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 551 KB

Fibroblasts cultured from affected skin areas of five patients with cutaneous scleroderma were found to produce increased amounts of collagen when compared with nonaffected control cells. Total RNA was isolated from the cultures and analyzed for its level of proal(1)collagen mRNA by hybridization of

Transfer of proα2(I) cDNA into cells of

Transfer of proα2(I) cDNA into cells of a murine model of human Osteogenesis Imperfecta restores synthesis of type I collagen comprised of α1(I) and α2(I) heterotrimers in vitro and in vivo

✍ Christopher Niyibizi; Patrick Smith; Zhibao Mi; Charlotte L. Phillips; Paul Robb 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB

## Abstract The __oim__ mouse is a model of human Osteogenesis Imperfecta (OI) that has deficient synthesis of proα2(I) chains. Cells isolated from __oim__ mice synthesize α1(I) collagen homotrimers that accumulate in tissues. To explore the feasibility of gene therapy for OI, a murine proα2(I) cDN