Procollagen gene expression by scleroderma fibroblasts in culture. inhibition of collagen production and reduction of proα(i) and proα1(III) collagen messenger RNA steady-state levels by retinoids

Inhibition of excessive scleroderma fibr

Inhibition of excessive scleroderma fibroblast collagen production by recombinant γ-interferon: Association with a coordinate decrease in types I and III procollagen messenger RNA levels

✍ Joel Rosenbloom; George Feldman; Bruce Freundlich; Sergio A. Jimenez 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 540 KB

The effects of recombinant gamma-interferon (rec gamma-IFN) on collagen production by confluent monolayer cultures of progressive systemic sclerosis (PSS) dermal fibroblasts were studied. Five cell lines obtained from patients with rapidly progressive disease of recent onset were examined. All PSS f