Coordinated Effects of Sequence Variation on DNA Binding, Chromatin Structure, and Transcription

✍ Scribed by Kilpinen, H.; Waszak, S. M.; Gschwind, A. R.; Raghav, S. K.; Witwicki, R. M.; Orioli, A.; Migliavacca, E.; Wiederkehr, M.; Gutierrez-Arcelus, M.; Panousis, N. I.; Yurovsky, A.; Lappalainen, T.; Romano-Palumbo, L.; Planchon, A.; Bielser, D.; Bryois, J.; Padioleau, I.; Udin, G.; Thurnheer, S.; Hacker, D.; Core, L. J.; Lis, J. T.; Hernandez, N.; Reymond, A.; Deplancke, B.; Dermitzakis, E. T.

• Book ID: 121355750
• Publisher: American Association for the Advancement of Science
• Year: 2013
• Tongue: English
• Weight: 486 KB
• Volume: 342
• Category: Article
• ISSN: 0036-8075
• DOI: 10.1126/science.1242463

✦ Synopsis

DNA Differences

The extent to which genetic variation affects an individual's phenotype has been difficult to predict because the majority of variation lies outside the coding regions of genes. Now, three studies examine the extent to which genetic variation affects the chromatin of individuals with diverse ancestry and genetic variation (see the Perspective by

Furey and Sethupathy

).
Kasowski
et al.
(p.
750
, published online 17 October) examined how genetic variation affects differences in chromatin states and their correlation to histone modifications, as well as more general DNA binding factors.
Kilpinen
et al.
(p.
744
, published online 17 October) document how genetic variation is linked to allelic specificity in transcription factor binding, histone modifications, and transcription.
McVicker
et al.
(p.
747
, published online 17 October) identified how quantitative trait loci affect histone modifications in Yoruban individuals and established which specific transcription factors affect such modifications.