Cooperativity of SV40 T antigen and ras in progressive stages of transformation of human fibroblasts
β Scribed by Jill A. White; Stephen G. Carter; Harvey L. Ozer; Ann L. Boyd
- Book ID
- 115892676
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 791 KB
- Volume
- 203
- Category
- Article
- ISSN
- 0014-4827
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The SV40 T antigen causes numerical (aneuploidy) and structural (aberrations) chromosome damage when expressed in human diploid fibroblasts. This chromosome damage precedes the acquisition of neoplastic traits such as anchorage independence, colony formation in reduced serum growth factors, immortal
## Abstract Early studies on the duration of mitotic stages and on metaphaseβtoβprophase ratios in a number of normal and neoplastic cells indicated that the process of mitosis becomes altered during the course of oncogenesis. However, the nature of these changes and their effects on each of the mi