Viral and cellular oncogene expression during progressive malignant transformation of SV40 transformed human fibroblasts

Malignant transformation of NIH 3T3 fibr

Malignant transformation of NIH 3T3 fibroblasts by human c-sis is dependent upon the level of oncogene expression

✍ Linda H. Macarthur; Michael F. Clarke; Eric H. Westin 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 996 KB

## Abstract High‐level expression of the c‐__sis__ oncogene, which encodes the β chain of platelet‐derived growth factor, transforms immortalized rodent fibroblasts in vitro to a malignant phenotype. c‐__sis__ gene expression has been demonstrated in a variety of human tumors, although generally at