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Cooperativity in Amide Hydrogen Bonding Chains. Relation between Energy, Position, and H-Bond Chain Length in Peptide and Protein Folding Models

✍ Scribed by Kobko, Nadya; Dannenberg, J. J.

Book ID
121185223
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
331 KB
Volume
107
Category
Article
ISSN
1089-5639

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A survey of 322 proteins showed that the short polar (SP) side chains of four residues, Thr, Ser, Asp, and Asn, have a very strong tendency to form hydrogen bonds with neighboring backbone amides. Specifically, 32% of Thr, 29% of Ser, 26% of Asp, and 19% of Asn engage in such hydrogen bonds. When an