A novel intramolecular hydrogen bonding between a side-chain pyridine ring and an amide hydrogen of the peptide backbone in tripeptides containing the new amino acid, ?,?-di(2-pyridyl)glycine

Studies on intramolecular hydrogen bondi

Studies on intramolecular hydrogen bonding between the pyridine nitrogen and the amide hydrogen of the peptide: synthesis and conformational analysis of tripeptides containing novel amino acids with a pyridine ring

✍ Masayuki Hanyu; Daisuke Ninomiya; Ryoji Yanagihara; Takashi Murashima; Toshifumi 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB

For the first time tripeptides, Z-AA(1)-Xaa-AA(3)-OMe (AA(1) and AA(3) = Gly or Aib, Xaa = 2Pmg and 2Pyg) were prepared containing alpha-methyl-alpha-(2-pyridyl)glycine (2Pmg) and alpha-(2-pyridyl)glycine (2Pyg) by solid-phase Ugi reaction. These results clearly indicate that for the preparation of