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Cooperative stabilization of Zn 2+ :DNA complexes through netropsin binding in the minor groove of FdU-substituted DNA

✍ Scribed by Ghosh, Supratim; Salsbury, Freddie R.; Horita, David A.; Gmeiner, William H.

Book ID
120595350
Publisher
Adenine Press
Year
2013
Tongue
English
Weight
729 KB
Volume
31
Category
Article
ISSN
0739-1102

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Accessibility of the minor groove of DNA
Accessibility of the minor groove of DNA in chromatin to the binding of antibiotics netropsin and distamycin A
✍ A. F. Melnikova; A. S. Zasedatelev; A. M. Kolchinsky; G. V. Gursky; A. L. Zhuze; πŸ“‚ Article πŸ“… 1975 πŸ› Springer 🌐 English βš– 380 KB

The interaction of the antibiotics distamycin A, distamycin analogue and netropsin with chromatin of calf thymus has been studied by circular dichroism measurements and by gel filtration. The minor groove of DNA in chromatin is accessible by 83-89% to the binding of these antibiotics as compared wit