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Cooperative catalysis of the cleavage of an amide by carboxylate and phenolic groups in a carboxypeptidase A model

✍ Scribed by Breslow, Ronald; McClure, David E.


Book ID
126906897
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
285 KB
Volume
98
Category
Article
ISSN
0002-7863

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Ab initio and semiempirical (AMl) molecular orbital theory has been used to model the cleavage of formamide at the active site of carboxypeptidase A. The model active site consists of a zinc dication coordinated to two imidazoles, an acetate, a water with a hydrogen-bonded formate, and a formamide m