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Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia

✍ Scribed by Cuenco, Grace M; Ren, Ruibao

Book ID
110066317
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
536 KB
Volume
20
Category
Article
ISSN
0950-9232

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## Abstract Jab1, a co‐activator of AP‐1 transcription factor and the fifth subunit of the COP9 signalosome, mediates degradation of the tumor suppressor p53 and p27^Kip1^ and functions as a tumor promoter in different types of human cancer. In this study, we show that inhibition of Bcr‐Abl oncogen