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Both AML1 and EVI1 oncogenic components are required for the cooperation of AML1/MDS1/EVI1 with BCR/ABL in the induction of acute myelogenous leukemia in mice

✍ Scribed by Cuenco, Grace M; Ren, Ruibao

Book ID: 110068225
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 442 KB
Volume: 23
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1207143

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## Abstract Rearrangements of chromosome band 3q26.2 lead to overexpression of the __EVI1__ gene and are associated with a poor prognosis in myeloid malignancies. __EVI1__ is also overexpressed in some cases without 3q26 rearrangements. To uncover its prognostic significance in this patient group,