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Converting a typical antipsychotic into an atypical one — The critical role of D2

✍ Scribed by S.C. VanderSpek; B.A. Brownlee; J. Nobrega; R. McClelland; P. Seeman; S. Kapur

Book ID
119555817
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
258 KB
Volume
60
Category
Article
ISSN
0920-9964

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The purpose of the present study was to assess the role of dopamine D 1 and D 2 receptors in the discriminative stimulus properties of the atypical antipsychotic clozapine (CLZ). Two groups of rats were trained to discriminate either a moderate dose of clozapine (5.0 mg/kg) from vehicle or a high do