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Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40

✍ Scribed by Levitsky, Hyam I.; Sotomayor, Eduardo M.; Borrello, Ivan; Tubb, Erev; Rattis, Frédérique-Marie; Bien, Harold; Lu, Zhengbin; Fein, Steve; Schoenberger, Stephen

Book ID: 109466586
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 393 KB
Volume: 5
Category: Article
ISSN: 1078-8956
DOI: 10.1038/10503

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## Abstract Naturally occurring CD4^+^ regulatory T cells can be identified on the basis of expression of CD25 and suppression of T cell responses __in vitro__ after TCR triggering. Here, we demonstrate that a CD134^+^ subset of CD4^+^CD25^+^ T cells in naive rats suppresses antigen‐specific T cell