Conversion of penicillin to cephalosporin via a double sulfoxide rearrangement
β Scribed by Spry, Douglas O.
- Book ID
- 121017958
- Publisher
- American Chemical Society
- Year
- 1970
- Tongue
- English
- Weight
- 320 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0002-7863
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8-Hydroxyquinoline (9) was converted to 8-aminequinoline (10) in a one-pot procedure involving alkylation with 2-bromo-2-methylpropionamide (2) followed by Smiles rearrangement and hydrolysis, in \(41 \%\) yield. The scope and limitations of this new procedure were explored with additional hydroxyqu